Ovagen
/ Khavinson-tradition liver/ovarian bioregulator (Glu-Asp-Leu and related)ALIAS · EDL · Liver/ovarian peptide bioregulator
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Tier 4. Khavinson-tradition short-peptide preparation positioned variably as a liver or ovarian bioregulator depending on vendor. The disclosed active sequence Glu-Asp-Leu (EDL) appears in Khavinson-group class-level reviews. No PubMed-indexed primary literature on Ovagen as a distinct preparation.
Ovagen is described in vendor materials as a Glu-Asp-Leu (EDL) tripeptide preparation. Within the Khavinson-tradition framework the claim is tissue-specific regulation of liver and ovarian cell gene expression. The molecular target has not been characterised in independent primary literature, and the same vendor channel markets EDL under both liver and ovarian indications without consistent disclosure of the basis for the dual claim.
Tier 4. No PubMed-indexed primary literature on Ovagen / EDL as a distinct molecular entity. Class-level Russian-origin reviews from the Khavinson group only.
No formal human safety database. General class concerns for Khavinson-tradition short-peptide preparations apply.
Regulatory status
- FDA status:
- Not FDA-approved
The Khavinson school (Saint-Petersburg Institute of Bioregulation and Gerontology) has published an extensive body of work on short-peptide 'bioregulators' derived from animal-tissue extracts, with a unifying claim that tissue-specific tetrapeptides (and shorter motifs) regulate gene expression and tissue-specific cell function. The corpus is Russian-origin and substantially self-cited; independent Western replication of the foundational findings has not been established.
Ovagen carries a particular indication-ambiguity issue: the same vendor preparation is marketed for liver and for ovarian use, with no independent published basis for the dual tissue claim. The tissue-specific framework that underpins the Khavinson tradition cannot consistently support a single peptide regulating two anatomically distinct tissues.