N-Acetyl-Selank
/ N-acetylated heptapeptide; Russian-origin nootropic; modified Selank for stabilityALIAS · NA-Selank · Acetylated Selank · Ac-Selank
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Tier 4. The N-acetylated form of Selank has effectively no presence in PubMed-indexed primary literature — vendor-marketed as an enhanced-stability variant of Selank without an independent published characterisation. The native (non-acetylated) Selank parent has Russian-language clinical literature; the acetylated derivative does not.
Native Selank (TKPRPGP) is a synthetic heptapeptide developed by the Institute of Molecular Genetics (Russian Academy of Sciences) as a modified analog of the immunomodulatory tetrapeptide tuftsin (TKPR), with three additional residues (PGP) intended to improve enzymatic stability. The N-acetylated derivative further blocks the free N-terminal amine to extend half-life against aminopeptidase cleavage. Mechanistic claims for the parent compound centre on GABAergic and serotonergic modulation, with reported anxiolytic effects in rodents and Russian clinical trial-like studies. Whether the acetylated derivative retains, modifies, or abolishes that activity has not been characterised in published primary literature.
Tier 4. No PubMed-indexed primary literature on the N-acetylated derivative specifically. Inference is from the parent Selank Russian clinical and rodent literature, which is not an evidentiary substitute.
No formal human safety database. The parent Selank has been used clinically in Russia with reported good tolerability in Russian-language literature; safety read-across to the acetylated derivative is not supported by direct data.
Regulatory status
- FDA status:
- Not FDA-approved
Russian-origin literature without independent Western replication — and the acetylated derivative specifically lacks even the Russian-language base of evidence that Selank itself accumulated. Vendor-marketed identity, purity, and pharmacology cannot be cross-checked against the published record.