Livagen
/ Khavinson-tradition tetrapeptide (Lys-Glu-Asp-Ala); proposed liver bioregulatorALIAS · KEDA · Lys-Glu-Asp-Ala · Liver peptide bioregulator
Terms in this page you can click for a plain-English popup: , , , , , , , .
Tier 4. Khavinson-tradition tetrapeptide Lys-Glu-Asp-Ala (KEDA) marketed as a liver bioregulator. PubMed-indexed primary literature is sparse and concentrates on chromatin-decondensation and lymphocyte-related effects from the Khavinson group; the claim of tissue-specific liver regulation rests on class-level reviews rather than independent organ-specific work.
Livagen is the synthetic tetrapeptide Lys-Glu-Asp-Ala (KEDA). Within the Khavinson-tradition framework the proposed mechanism is direct interaction with chromatin and promoter regions, with reported in-vitro effects on chromatin decondensation in lymphocytes and modulation of cytokine expression. The tissue-specific liver regulation claim is asserted by analogy to the broader tissue-specific peptide framework rather than from organ-targeted experimental work.
Tier 4. The available PubMed-indexed primary literature is in-vitro and from the Khavinson group, principally on lymphocyte chromatin and cytokine effects. No human clinical-trial data.
No formal human safety database. General Khavinson-tradition short-peptide class concerns (identity, purity, vendor manufacturing) apply.
Regulatory status
- FDA status:
- Not FDA-approved
The Khavinson school (Saint-Petersburg Institute of Bioregulation and Gerontology) has published an extensive body of work on short-peptide 'bioregulators' derived from animal-tissue extracts, with a unifying claim that tissue-specific tetrapeptides (and shorter motifs) regulate gene expression and tissue-specific cell function. The corpus is Russian-origin and substantially self-cited; independent Western replication of the foundational findings has not been established.
The disconnect between published Livagen primary literature (lymphocyte chromatin / cytokine in vitro) and vendor marketing (liver tissue regulation) is not bridged by published organ-specific experimental data.