Kisspeptin-10
/ 10-amino-acid C-terminal fragment of kisspeptin; KISS1R (GPR54) receptor agonistALIAS · KP-10 · Metastin 45-54
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Substantial academic research interest in reproductive endocrinology — kisspeptin triggers GnRH release. Several Phase 1/2 academic trials exist (e.g., UK Imperial College group). Not an FDA-approved therapeutic.
Kisspeptin-10 is the C-terminal 10 amino acids of the 54-amino-acid kisspeptin peptide encoded by KISS1. It is a potent agonist at KISS1R (formerly GPR54) and triggers GnRH release from hypothalamic GnRH neurons. Central to the hypothalamic control of the reproductive axis.
Several Phase 1/2 academic trials have evaluated kisspeptin infusion for conditions including hypothalamic amenorrhea, infertility-adjacent indications, and diagnostic applications (triggering oocyte maturation in IVF). Imperial College London group is a major research center. Not FDA-approved for any therapeutic use.
Academic trials at research doses have reported generally favorable tolerability with mild flushing and short-lived infusion-related effects. Long-term safety data from chronic administration is not available.
Regulatory status
- FDA status:
- Not FDA-approved
Kisspeptin is a well-characterized research peptide with legitimate academic clinical investigation, but popular-press marketing claims (libido, body composition, etc.) outrun the specific reproductive-endocrinology indications under study.