Peptides›Metabolic›Dulaglutide

Dulaglutide

/ GLP-1 analog fused to IgG4 Fc fragment; long-acting GLP-1 receptor agonist

TIER 1 · ClinicalN = 0 · TESTING PENDINGLAST REVIEW 2026·04·20

ALIAS · Trulicity

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Research use onlyAny dose figures below describe what specific cited studies used, reported factually. Nothing on this page is guidance for human use.READ FIRST →

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§ A · Identity

Primary sequence— sequence not captured —

MW · —CLASS · GLP-1 analog fused to IgG4 Fc fragment; long-acting GLP-1 receptor agonistCATEGORY · Metabolic

FDA-approved for type 2 diabetes (2014). Eli Lilly's once-weekly GLP-1 predecessor to tirzepatide.

§ B · Mechanism of action

Dulaglutide is a GLP-1 analog fused to an IgG4 Fc fragment. The Fc fusion confers neonatal Fc receptor (FcRn) recycling and a half-life of approximately 5 days, enabling once-weekly subcutaneous dosing. AWARD clinical program established efficacy in type 2 diabetes.

§ C · Human clinical evidence

Extensive. AWARD program supported FDA approval. REWIND cardiovascular outcomes trial (Gerstein 2019, Lancet) demonstrated MACE reduction in T2DM with and without established CV disease.

§ D · Primary literature

PubMed31189511Gerstein HC et al. — Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial · Lancet · human-phase-3-rctOnce-weekly dulaglutide reduced major adverse cardiovascular events by 12% versus placebo over 5.4 years in 9,901 T2DM patients with cardiovascular risk factors or established disease.Limitations: Mixed primary/secondary prevention cohort.2019

§ F · Safety signal

Class GLP-1 adverse event profile. Same thyroid C-cell boxed warning, pancreatitis, gallbladder disease, and AKI warnings. Discontinuation rates for GI events modestly lower than early-generation GLP-1 agonists.

§ H · Regulatory status

Regulatory status

FDA status:: FDA-approved
Compounding:: Not eligible for compounding (approved, not in shortage)